

| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 3:34pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:34pm CT |
| Started | QB | Kirk Cousins ATL | Owner | Sat Nov 29 11:15am CT |
| Benched | QB | Sam Darnold SEA | Owner | Sat Nov 29 11:15am CT |
| Started | RB | Jaleel McLaughlin DEN | Owner | Sat Nov 29 11:15am CT |
| Started | RB | Zach Charbonnet SEA | Owner | Sat Nov 29 11:15am CT |
| Benched | RB | RJ Harvey DEN | Owner | Sat Nov 29 11:15am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Sat Nov 29 11:15am CT |
| Benched | QB | Jaxson Dart NYG | Owner | Fri Nov 28 8:00pm CT |
| Benched | WR | Malik Washington MIA | Owner | Fri Nov 28 8:00pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Fri Nov 28 8:00pm CT |
| Started | QB | Kirk Cousins ATL | Owner | Fri Nov 28 8:00pm CT |
| Started | WR | Ricky Pearsall SF | Owner | Fri Nov 28 8:00pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Fri Nov 28 8:00pm CT |
| Benched | RB | Jaleel McLaughlin DEN | Owner | Fri Nov 28 1:30pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Fri Nov 28 1:30pm CT |
| Benched | TE | Mason Taylor NYJ | Owner | Fri Nov 28 1:30pm CT |
| Started | QB | Sam Darnold SEA | Owner | Fri Nov 28 1:30pm CT |
| Started | RB | RJ Harvey DEN | Owner | Fri Nov 28 1:30pm CT |
| Started | WR | Rome Odunze CHI | Owner | Fri Nov 28 1:30pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Fri Nov 28 1:30pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Fri Nov 28 1:30pm CT |
| Benched | QB | Kirk Cousins ATL | Owner | Fri Nov 28 1:30pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 1:30pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Wed Nov 26 5:17pm CT |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 5:17pm CT |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 5:17pm CT |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 26 5:17pm CT |
| Benched | RB | RJ Harvey DEN | Owner | Wed Nov 26 5:17pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 5:17pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 5:17pm CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 5:17pm CT |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 26 5:17pm CT |
| Started | QB | Kirk Cousins ATL | Owner | Wed Nov 26 5:17pm CT |
| Started | TE | Juwan Johnson NO | Owner | Wed Nov 26 5:17pm CT |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 5:17pm CT |
| Started | RB | Jaleel McLaughlin DEN | Owner | Wed Nov 26 5:17pm CT |
| Started | WR | Ricky Pearsall SF | Owner | Wed Nov 26 5:17pm CT |
| Started | RB | Jordan Mason MIN | Owner | Wed Nov 26 5:17pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Wed Nov 26 5:17pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:44pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 3:44pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 3:44pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 3:44pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 5:28pm CT |
| Benched | WR | Sterling Shepard TB | Owner | Tue Nov 25 5:28pm CT |
| Benched | WR | Olamide Zaccheaus CHI | Owner | Tue Nov 25 5:28pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:28pm CT |
| Started | WR | Elic Ayomanor TEN | Owner | Tue Nov 25 5:28pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:28pm CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Thu Nov 27 12:36am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 12:36am CT |
| Started | RB | Dylan Sampson CLE | Owner | Thu Nov 27 12:36am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 12:36am CT |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 11:49am CT |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 11:49am CT |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 27 11:49am CT |
| Started | RB | Jaylen Warren PIT | Owner | Thu Nov 27 11:49am CT |
| Benched | WR | Jauan Jennings SF | Owner | Fri Nov 28 10:57am CT |
| Started | WR | Jordan Addison MIN | Owner | Fri Nov 28 10:57am CT |
| Benched | WR | Jordan Addison MIN | Owner | Fri Nov 28 10:57am CT |
| Started | WR | John Metchie III NYJ | Owner | Fri Nov 28 10:57am CT |
| Started | WR | Chimere Dike TEN | Owner | Thu Nov 27 2:47am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 7:22pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 7:22pm CT |
| Benched | RB | Bucky Irving TB | Owner | Fri Nov 28 7:47pm CT |
| Started | RB | Woody Marks HOU | Owner | Fri Nov 28 7:47pm CT |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 11:21am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 11:21am CT |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 10:05am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 10:05am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 6:56am CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 6:56am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 2:24pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:24pm CT |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 2:20pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 2:20pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 5:32am CT |
| Started | RB | Omarion Hampton LAC | Owner | Thu Nov 27 5:32am CT |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 4:22am CT |
| Benched | TE | Noah Fant CIN | Owner | Thu Nov 27 4:22am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 4:22am CT |
| Started | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 4:22am CT |
| Benched | TE | Dalton Schultz HOU | Owner | Sat Nov 29 9:25pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 9:25pm CT |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 10:31pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 10:31pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 10:31pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 10:31pm CT |
| No starting lineup changes performed this week. |