

| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 4 10:38am ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 10:38am ET |
| Started | TE | Terrance Ferguson LAR | Owner | Fri Nov 7 8:07am ET |
| Started | QB | Justin Herbert LAC | Owner | Fri Nov 7 8:07am ET |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Fri Nov 7 8:07am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Fri Nov 7 8:07am ET |
| Started | WR | Jauan Jennings SF | Owner | Thu Nov 6 10:05am ET |
| Benched | RB | Tank Bigsby PHI | Owner | Thu Nov 6 10:05am ET |
| Started | RB | Tank Bigsby PHI | Owner | Thu Nov 6 10:05am ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 6 10:05am ET |
| Started | RB | Saquon Barkley PHI | Owner | Thu Nov 6 10:03am ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Thu Nov 6 10:03am ET |
| Started | K | Cam Little JAX | Owner | Thu Nov 6 10:03am ET |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 4:32pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 6 4:31pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 5 11:56pm ET |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 11:56pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 5 11:56pm ET |
| Started | RB | J.K. Dobbins DEN | Owner | Wed Nov 5 11:56pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 5 8:21pm ET |
| Started | TE | Cade Otton TB | Owner | Wed Nov 5 8:21pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 4 7:19pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 7:19pm ET |
| Benched | QB | Mac Jones SF | Owner | Tue Nov 4 11:11am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 11:11am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 5 9:59am ET |
| Benched | WR | D.J. Moore CHI | Owner | Wed Nov 5 9:59am ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 5 9:59am ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 5 9:59am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 6 6:38am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 10:21am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 10:21am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 10:21am ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 4 10:21am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 4 10:21am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 10:21am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Sat Nov 8 8:05am ET |
| Started | RB | Rico Dowdle CAR | Owner | Sat Nov 8 8:05am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 7:08am ET |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 4 7:08am ET |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 4 7:08am ET |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 7:08am ET |
| Benched | RB | Devin Neal NO | Owner | Wed Nov 5 7:59pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Wed Nov 5 7:59pm ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 7:59pm ET |
| Started | TE | Brock Bowers LV | Owner | Wed Nov 5 7:59pm ET |
| Started | K | Jake Elliott PHI | Owner | Thu Nov 6 4:34am ET |
| Started | RB | Emari Demercado ARI | Owner | Thu Nov 6 4:34am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 5:47pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 5:47pm ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 5:47pm ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 5:47pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 4 5:47pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 4 5:47pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 5:47pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 5:47pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 6 4:50am ET |
| Benched | QB | Aaron Rodgers PIT | Owner | Tue Nov 4 4:40pm ET |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 4:40pm ET |
| No starting lineup changes performed this week. |