

| Benched | RB | Trey Benson ARI | Owner | Fri Nov 28 12:38pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Fri Nov 28 12:38pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 1:15am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 1:15am ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 9:32pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Nov 26 6:50am ET |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 10:38am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 10:36am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 12:10am ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 7:18am ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 7:18am ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 7:18am ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 7:18am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 7:18am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:18am ET |
| Started | K | Cam Little JAX | Owner | Sun Nov 30 2:24am ET |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 26 10:20am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:20am ET |
| Started | QB | Jalen Hurts PHI | Owner | Wed Nov 26 10:20am ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 10:20am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Sun Nov 30 12:24am ET |
| Started | WR | Jayden Higgins HOU | Owner | Sun Nov 30 12:24am ET |
| Benched | K | Andres Borregales NE | Owner | Thu Nov 27 9:58am ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 9:58am ET |
| Benched | WR | Michael Wilson ARI | Owner | Tue Nov 25 5:11pm ET |
| Benched | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 25 5:11pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 5:11pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:11pm ET |
| Started | K | Andres Borregales NE | Owner | Tue Nov 25 5:11pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 5:11pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 6:06pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Wed Nov 26 6:06pm ET |
| Started | QB | Daniel Jones IND | Owner | Wed Nov 26 6:06pm ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 26 6:06pm ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:27pm ET |
| Benched | TE | AJ Barner SEA | Owner | Wed Nov 26 10:27pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:27pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 10:27pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 4:07pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:07pm ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 1:26am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 1:26am ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 6:57pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 6:57pm ET |
| Benched | TE | George Kittle SF | Owner | Tue Nov 25 6:57pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 6:57pm ET |
| Started | RB | James Cook BUF | Owner | Tue Nov 25 6:57pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:57pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 26 7:05am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 7:05am ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Wed Nov 26 7:05am ET |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 7:05am ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 25 8:27pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 8:27pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 8:27pm ET |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 8:27pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:27pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:27pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:27pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:27pm ET |
| No starting lineup changes performed this week. |