

| No starting lineup changes performed this week. |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 7:02am ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 18 7:02am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 10:22am ET |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 18 10:22am ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 18 10:22am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 18 10:22am ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 18 8:37am ET |
| Started | TE | Dalton Schultz HOU | Owner | Tue Nov 18 8:37am ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 9:47am ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 18 9:47am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 18 9:47am ET |
| Started | TE | Gunnar Helm TEN | Owner | Tue Nov 18 9:47am ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 18 11:20am ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 18 11:20am ET |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 18 11:18am ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 11:18am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 11:18am ET |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 11:18am ET |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 18 11:18am ET |
| Benched | RB | Justice Hill BAL | Owner | Tue Nov 18 10:36am ET |
| Benched | TE | Michael Mayer LV | Owner | Tue Nov 18 10:36am ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 18 10:36am ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 18 10:36am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |