

| No starting lineup changes performed this week. |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 7:28am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:28am CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 6:09pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 6:09pm CT |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 6:09pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 6:09pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Fri Nov 28 10:44am CT |
| Started | TE | Brenton Strange JAX | Owner | Fri Nov 28 10:44am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 3:46pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 3:46pm CT |
| Benched | TE | Brenton Strange JAX | Owner | Tue Nov 25 3:46pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 3:46pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 3:46pm CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 3:46pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:27am CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:27am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:27am CT |
| Started | WR | Josh Downs IND | Owner | Wed Nov 26 10:27am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 1:13pm CT |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 1:13pm CT |
| Started | QB | Kirk Cousins ATL | Owner | Wed Nov 26 11:21pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 11:21pm CT |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 25 7:32am CT |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 7:26am CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 7:26am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:26am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 7:26am CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 7:26am CT |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 7:26am CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 7:26am CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 7:26am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 7:26am CT |
| Benched | K | Jake Bates DET | Owner | Thu Nov 27 8:50am CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 8:50am CT |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Nov 26 5:08pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 5:08pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 11:51am CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 11:51am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:51am CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 25 11:51am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 10:51pm CT |
| Started | WR | Alec Pierce IND | Owner | Sat Nov 29 10:51pm CT |
| Benched | WR | Alec Pierce IND | Owner | Sat Nov 29 10:51pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 10:51pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 11:31am CT |
| Benched | QB | Cam Ward TEN | Owner | Thu Nov 27 11:44am CT |
| Started | QB | Bryce Young CAR | Owner | Thu Nov 27 11:44am CT |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 11:43am CT |
| Started | QB | Cam Ward TEN | Owner | Thu Nov 27 11:43am CT |
| Benched | TE | Noah Fant CIN | Owner | Wed Nov 26 12:35pm CT |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 12:35pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 10:40am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 10:40am CT |
| Benched | D/ST | Tennessee Titans TEN | Owner | Thu Nov 27 10:40am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 10:40am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 10:40am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 10:40am CT |