

| Benched | WR | Tetairoa McMillan CAR | Owner | Thu Nov 27 9:28am CT |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 9:28am CT |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 8:48am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 8:48am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 8:47am CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 8:47am CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 8:47am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:47am CT |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 3:23pm CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:23pm CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 3:13pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:13pm CT |
| Benched | WR | Demario Douglas NE | Owner | Wed Nov 26 9:17pm CT |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 9:17pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:17pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 9:17pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 9:17pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 9:17pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:16pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:16pm CT |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 27 11:33am CT |
| Started | TE | Harold Fannin Jr. CLE | Owner | Thu Nov 27 11:33am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 11:32am CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 11:21pm CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 11:21pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 11:21pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 11:21pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 1:07pm CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 1:07pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 1:07pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:07pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 1:07pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:07pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 8:50am CT |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 25 8:50am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 8:49am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:49am CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 10:43pm CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 10:43pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:43pm CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 10:43pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:43pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 10:43pm CT |
| Benched | QB | Aidan O'Connell LV | Owner | Tue Nov 25 4:59pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 4:59pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 3:22pm CT |
| Started | RB | Rachaad White TB | Owner | Wed Nov 26 3:22pm CT |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 3:23pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 3:23pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 3:23pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:23pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 10:26am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 10:26am CT |