

| Benched | QB | Brock Purdy SF | Owner | Sat Nov 29 5:28pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Sat Nov 29 5:28pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 27 4:06pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 4:06pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 12:52am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:52am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 12:52am ET |
| Benched | RB | Justice Hill BAL | Owner | Wed Nov 26 9:52pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 9:52pm ET |
| Started | RB | Jeremy McNichols WAS | Owner | Wed Nov 26 9:52pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:52pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Sat Nov 29 6:50am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 6:50am ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 4:38pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:38pm ET |
| Started | RB | Ollie Gordon II MIA | Owner | Sat Nov 29 9:10pm ET |
| Benched | RB | Omarion Hampton LAC | Owner | Sat Nov 29 9:10pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:18pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:18pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:18pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 9:18pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 9:18pm ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 9:18pm ET |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 9:18pm ET |
| Benched | WR | KhaDarel Hodge ATL | Owner | Tue Nov 25 9:18pm ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 9:18pm ET |
| Benched | RB | Tank Bigsby PHI | Owner | Tue Nov 25 9:18pm ET |
| Started | QB | Justin Fields NYJ | Owner | Sat Nov 29 11:26am ET |
| Benched | QB | C.J. Stroud HOU | Owner | Sat Nov 29 11:26am ET |
| Started | RB | Jaleel McLaughlin DEN | Owner | Thu Nov 27 11:26pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 11:26pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 4:06pm ET |
| Benched | QB | Justin Fields NYJ | Owner | Thu Nov 27 4:06pm ET |
| Started | WR | Jordan Addison MIN | Owner | Thu Nov 27 2:42pm ET |
| Benched | WR | Efton Chism III NE | Owner | Thu Nov 27 2:42pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 12:32pm ET |
| Started | WR | Efton Chism III NE | Owner | Thu Nov 27 12:32pm ET |
| Started | WR | Elic Ayomanor TEN | Owner | Wed Nov 26 5:43pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 5:43pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 26 5:43pm ET |
| Benched | RB | RJ Harvey DEN | Owner | Wed Nov 26 5:43pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 11:48am ET |
| Started | QB | Justin Fields NYJ | Owner | Wed Nov 26 11:48am ET |
| Benched | RB | Kyren Williams LAR | Owner | Wed Nov 26 11:48am ET |
| Benched | QB | C.J. Stroud HOU | Owner | Wed Nov 26 11:48am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 26 11:46am ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 11:46am ET |
| Started | RB | Brashard Smith KC | Owner | Wed Nov 26 11:46am ET |
| Started | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 11:46am ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 5:36pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 5:36pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 5:36pm ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 25 5:36pm ET |
| Benched | WR | Efton Chism III NE | Owner | Tue Nov 25 5:36pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 5:36pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:36pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 5:36pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Nov 25 5:36pm ET |
| Benched | QB | Justin Fields NYJ | Owner | Tue Nov 25 5:36pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Sat Nov 29 5:59am ET |
| Started | RB | Tyjae Spears TEN | Owner | Sat Nov 29 5:59am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 6:24pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:24pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 6:37pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 6:37pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 6:37pm ET |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 6:37pm ET |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 11:39am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Wed Nov 26 11:39am ET |
| Started | QB | Dak Prescott DAL | Owner | Wed Nov 26 11:39am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:39am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 12:09pm ET |
| Started | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 12:09pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 12:09pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 12:09pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 12:09pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 12:09pm ET |
| Benched | WR | Parker Washington JAX | Owner | Thu Nov 27 12:39pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 12:39pm ET |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 12:38pm ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 12:38pm ET |
| No starting lineup changes performed this week. |