

| Benched | TE | Zach Ertz WAS | Owner | Fri Nov 28 7:46pm CT |
| Started | WR | Greg Dortch ARI | Owner | Fri Nov 28 7:46pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 3:36pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 3:36pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:36pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:36pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 26 8:52am CT |
| Started | WR | Isaiah Bond CLE | Owner | Wed Nov 26 8:52am CT |
| Benched | TE | Elijah Arroyo SEA | Owner | Wed Nov 26 8:51am CT |
| Started | TE | Terrance Ferguson LAR | Owner | Wed Nov 26 8:51am CT |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 8:51am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Wed Nov 26 8:51am CT |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 3:11pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 3:11pm CT |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 9:50pm CT |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 9:50pm CT |
| Benched | TE | Tyler Warren IND | Owner | Wed Nov 26 9:50pm CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 9:50pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 9:50pm CT |
| Started | TE | Travis Kelce KC | Owner | Wed Nov 26 9:50pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 10:04pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 10:03pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 10:03pm CT |
| Started | WR | Alec Pierce IND | Owner | Wed Nov 26 8:56pm CT |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 8:56pm CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 9:36am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 9:36am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:36am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:36am CT |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 9:36am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:36am CT |
| Benched | WR | Demario Douglas NE | Owner | Tue Nov 25 9:36am CT |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 9:36am CT |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 7:32am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 7:32am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 10:23am CT |
| Benched | TE | Jonnu Smith PIT | Owner | Tue Nov 25 10:23am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 10:23am CT |
| Started | WR | Marvin Mims DEN | Owner | Tue Nov 25 10:23am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 6:12pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 6:12pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 6:12pm CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 6:12pm CT |
| Started | WR | Malik Washington MIA | Owner | Sat Nov 29 6:41pm CT |
| Benched | WR | Parker Washington JAX | Owner | Sat Nov 29 6:41pm CT |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 12:22pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 12:22pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 2:28pm CT |
| Started | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 2:28pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 2:28pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:28pm CT |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 2:28pm CT |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 2:28pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 2:28pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 2:28pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 11:38am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 11:38am CT |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 11:38am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 11:38am CT |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 11:38am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:38am CT |
| No starting lineup changes performed this week. |