

| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 12:56pm ET |
| Started | RB | David Montgomery DET | Owner | Thu Nov 27 12:56pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Thu Nov 27 3:59am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 3:59am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 27 3:58am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 7:09pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 7:09pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:09pm ET |
| Started | QB | Kirk Cousins ATL | Owner | Tue Nov 25 7:09pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:09pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 7:09pm ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 1:37pm ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 1:37pm ET |
| Started | TE | Mike Gesicki CIN | Owner | Thu Nov 27 12:20am ET |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 6:37pm ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Nov 25 6:37pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:37pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 6:37pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 7:12pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 1:22am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 5:47pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 5:47pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 5:47pm ET |
| Benched | K | Jake Bates DET | Owner | Tue Nov 25 5:47pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:47pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 5:47pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 5:47pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 2:19pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 2:19pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 11:07pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:07pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | TE | Dallas Goedert PHI | Owner | Fri Nov 28 2:55pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Fri Nov 28 2:55pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 7:36pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 7:36pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:19pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 3:19pm ET |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 12:53pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 25 12:53pm ET |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 25 12:53pm ET |
| Benched | K | Cairo Santos CHI | Owner | Tue Nov 25 12:53pm ET |
| Started | K | Wil Lutz DEN | Owner | Thu Nov 27 4:40pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 7:41am ET |
| Benched | WR | Keon Coleman BUF | Owner | Wed Nov 26 7:41am ET |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 7:41am ET |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 7:41am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 7:41am ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 7:41am ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 9:39am ET |
| Benched | WR | Tyler Lockett LV | Owner | Tue Nov 25 9:39am ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 9:39am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 9:39am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 9:39am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:39am ET |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 2:29am ET |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 2:29am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 11:07pm ET |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 11:07pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 11:07pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 11:07pm ET |