

| Started | TE | Hunter Henry NE | Owner | Sat Nov 22 9:38pm ET |
| Benched | WR | Tez Johnson TB | Owner | Sat Nov 22 9:38pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 20 5:01pm ET |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 19 11:28pm ET |
| Started | TE | Tyler Warren IND | Owner | Wed Nov 19 11:28pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Wed Nov 19 11:28pm ET |
| Started | QB | Tyler Shough NO | Owner | Wed Nov 19 11:28pm ET |
| Benched | TE | Dawson Knox BUF | Owner | Wed Nov 19 11:28pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 19 11:28pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 19 11:28pm ET |
| Benched | QB | Bo Nix DEN | Owner | Wed Nov 19 11:28pm ET |
| Started | RB | Rhamondre Stevenson NE | system | Sun Nov 23 4:40am ET |
| Benched | WR | Ladd McConkey LAC | system | Sun Nov 23 4:40am ET |
| Started | TE | Harold Fannin Jr. CLE | system | Sun Nov 23 4:40am ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 20 7:26pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Thu Nov 20 7:26pm ET |
| Started | RB | Alvin Kamara NO | Owner | Thu Nov 20 7:26pm ET |
| Started | WR | Luther Burden III CHI | Owner | Thu Nov 20 7:26pm ET |
| No starting lineup changes performed this week. |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 20 9:24am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Wed Nov 19 12:26pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Sat Nov 22 3:30pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Sat Nov 22 3:30pm ET |
| Started | K | Evan McPherson CIN | Owner | Thu Nov 20 12:06am ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 18 9:24am ET |
| Started | WR | Ricky Pearsall SF | Owner | Tue Nov 18 9:24am ET |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 7:32am ET |
| Started | K | Cairo Santos CHI | Owner | Thu Nov 20 8:20am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Thu Nov 20 8:20am ET |
| Benched | RB | Devon Achane MIA | Owner | Wed Nov 19 2:43pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 19 2:43pm ET |
| Started | RB | Blake Corum LAR | Owner | Wed Nov 19 2:43pm ET |
| Started | WR | Chris Olave NO | Owner | Wed Nov 19 2:43pm ET |
| Benched | QB | Justin Herbert LAC | Owner | Thu Nov 20 5:19am ET |
| Started | QB | Bryce Young CAR | Owner | Thu Nov 20 5:19am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 18 9:20pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 9:20pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 19 11:00am ET |
| Benched | RB | RJ Harvey DEN | Owner | Wed Nov 19 11:00am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Wed Nov 19 11:00am ET |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 19 11:00am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 19 11:00am ET |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 19 11:00am ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 18 1:51pm ET |
| Benched | RB | Jerome Ford CLE | Owner | Tue Nov 18 1:51pm ET |
| Benched | WR | JuJu Smith-Schuster KC | Owner | Tue Nov 18 1:51pm ET |
| Started | QB | Josh Allen BUF | Owner | Tue Nov 18 1:51pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 18 1:51pm ET |
| Started | WR | Xavier Legette CAR | Owner | Tue Nov 18 1:51pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 6:42pm ET |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 18 6:42pm ET |
| Benched | QB | Aaron Rodgers PIT | Owner | Thu Nov 20 6:14pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Thu Nov 20 6:14pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Thu Nov 20 6:14pm ET |
| Started | QB | Caleb Williams CHI | Owner | Thu Nov 20 6:14pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 20 6:14pm ET |