

| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 9:44pm CT |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 9:44pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:44pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:44pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 2:26am CT |
| Benched | TE | Dalton Schultz HOU | Owner | Thu Nov 27 2:26am CT |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 2:26am CT |
| Started | TE | Colston Loveland CHI | Owner | Thu Nov 27 2:26am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Fri Nov 28 1:15pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Fri Nov 28 1:15pm CT |
| Started | WR | Jakobi Meyers JAX | Owner | Thu Nov 27 8:01am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 8:01am CT |
| Benched | WR | Parker Washington JAX | Owner | Thu Nov 27 8:01am CT |
| Benched | RB | Nick Chubb HOU | Owner | Thu Nov 27 8:01am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:18pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:18pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 8:18pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 8:18pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 8:18pm CT |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 8:18pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 8:53am CT |
| Benched | WR | Malik Washington MIA | Owner | Sat Nov 29 8:53am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 8:03am CT |
| Benched | WR | John Metchie III NYJ | Owner | Sat Nov 29 8:03am CT |
| Started | WR | John Metchie III NYJ | Owner | Fri Nov 28 8:28am CT |
| Benched | WR | Terry McLaurin WAS | Owner | Fri Nov 28 8:28am CT |
| Started | WR | Malik Washington MIA | Owner | Thu Nov 27 7:24am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Thu Nov 27 7:24am CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 6:09pm CT |
| Benched | WR | Malik Washington MIA | Owner | Tue Nov 25 6:09pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 10:56am CT |
| Benched | WR | Terry McLaurin WAS | Owner | Tue Nov 25 10:56am CT |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 7:35am CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 7:35am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 7:35am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 7:35am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 8:28am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 8:28am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:28am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:28am CT |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 9:59pm CT |
| Started | WR | Luther Burden III CHI | Owner | Wed Nov 26 9:59pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 3:23pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:23pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 8:10am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:10am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 8:10am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:10am CT |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 8:40am CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 8:40am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 8:40am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:40am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 9:20am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:20am CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 6:45am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 6:45am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 5:23pm CT |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 5:23pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 5:23pm CT |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 5:23pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 5:23pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 5:23pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:23pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 5:23pm CT |