

| Started | RB | Bucky Irving TB | system | Sun Nov 30 6:26am ET |
| Benched | RB | Justice Hill BAL | system | Thu Nov 27 6:26am ET |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 4:43pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:43pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:12pm ET |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 3:12pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 8:49am ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 8:49am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 7:13pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 7:13pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 9:14pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:14pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 7:28am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 7:28am ET |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 11:00pm ET |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 11:00pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 11:00pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 11:00pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 10:17am ET |
| Benched | WR | Xavier Legette CAR | Owner | Thu Nov 27 10:17am ET |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 10:17am ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 10:17am ET |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 11:01pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 11:01pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 11:40am ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 11:40am ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Sat Nov 29 8:33am ET |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 8:33am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 4:28pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 27 4:28pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 4:28pm ET |
| Benched | WR | Tee Higgins CIN | system | Thu Nov 27 6:26am ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 8:41am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:41am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 8:40am ET |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 8:40am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:40am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:40am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 2:39pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:39pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 8:50am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 8:50am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:50am ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 8:50am ET |