

| Started | RB | Bucky Irving TB | system | Sun Nov 30 5:26am CT |
| Benched | RB | Justice Hill BAL | system | Thu Nov 27 5:26am CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 3:43pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:43pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 2:12pm CT |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 2:12pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 7:49am CT |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 7:49am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 6:13pm CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 6:13pm CT |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 8:14pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:14pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 6:28am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 6:28am CT |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 10:00pm CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 10:00pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 10:00pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 10:00pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 9:17am CT |
| Benched | WR | Xavier Legette CAR | Owner | Thu Nov 27 9:17am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 9:17am CT |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 9:17am CT |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 10:01pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 10:01pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 10:40am CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:40am CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Sat Nov 29 7:33am CT |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 7:33am CT |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 3:28pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 27 3:28pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 3:28pm CT |
| Benched | WR | Tee Higgins CIN | system | Thu Nov 27 5:26am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 7:41am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:41am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 7:40am CT |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 7:40am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:40am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:40am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 1:39pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 1:39pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 7:50am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 7:50am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:50am CT |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 7:50am CT |