

| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 2:07pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Oct 28 2:07pm CT |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 2:07pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Tue Oct 28 2:07pm CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 6:57am CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Oct 28 6:57am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Oct 28 6:57am CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 6:57am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 6:57am CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 6:57am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Oct 28 6:14am CT |
| Benched | WR | Calvin Austin III PIT | Owner | Tue Oct 28 6:14am CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 6:14am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 6:14am CT |
| Benched | QB | Tyler Huntley BAL | Owner | Tue Oct 28 3:55pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Oct 28 3:55pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 3:55pm CT |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 3:55pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Oct 28 3:55pm CT |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Oct 28 3:55pm CT |
| Started | WR | Travis Hunter JAX | Owner | Tue Oct 28 3:55pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Oct 28 11:39am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 11:39am CT |
| Started | WR | Matthew Golden GB | Owner | Tue Oct 28 11:38am CT |
| Benched | RB | Zavier Scott MIN | Owner | Tue Oct 28 11:38am CT |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 10:58am CT |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 10:58am CT |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 10:58am CT |
| Started | RB | Zavier Scott MIN | Owner | Tue Oct 28 10:58am CT |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 10:58am CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 10:58am CT |
| Benched | WR | Luke McCaffrey WAS | Owner | Tue Oct 28 10:58am CT |
| Benched | WR | Matthew Golden GB | Owner | Tue Oct 28 10:58am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 10:58am CT |
| Benched | RB | Justice Hill BAL | Owner | Tue Oct 28 10:58am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | RB | Michael Carter ARI | Owner | Tue Oct 28 1:37pm CT |
| Started | RB | DJ Giddens IND | Owner | Tue Oct 28 1:37pm CT |
| Started | WR | Tory Horton SEA | Owner | Tue Oct 28 1:37pm CT |
| Started | WR | Tez Johnson TB | Owner | Tue Oct 28 1:37pm CT |
| Benched | QB | Spencer Rattler NO | Owner | Tue Oct 28 6:16am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 6:16am CT |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 6:16am CT |
| Started | QB | Geno Smith LV | Owner | Tue Oct 28 6:16am CT |
| Started | WR | Jakobi Meyers LV | Owner | Tue Oct 28 6:16am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 1:30pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 1:30pm CT |
| Started | RB | David Montgomery DET | Owner | Tue Oct 28 1:30pm CT |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 1:30pm CT |