

| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 18 4:39pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 18 4:39pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 18 4:39pm ET |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 18 4:39pm ET |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 9:43am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 9:43am ET |
| Started | RB | David Montgomery DET | Owner | Tue Nov 18 9:43am ET |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 18 9:43am ET |
| No starting lineup changes performed this week. |
| Started | QB | Bryce Young CAR | Owner | Thu Nov 20 12:30am ET |
| Benched | QB | Marcus Mariota WAS | Owner | Tue Nov 18 6:36pm ET |
| Benched | WR | Malik Washington MIA | Owner | Wed Nov 19 7:46pm ET |
| Started | WR | Mack Hollins NE | Owner | Wed Nov 19 7:46pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Wed Nov 19 7:45pm ET |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 19 7:45pm ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Wed Nov 19 7:37pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 19 7:37pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 19 7:37pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Wed Nov 19 7:37pm ET |
| Benched | QB | Aaron Rodgers PIT | Owner | Thu Nov 20 9:03am ET |
| Started | QB | Brock Purdy SF | Owner | Thu Nov 20 9:03am ET |
| Started | K | Harrison Butker KC | Owner | Thu Nov 20 9:03am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 18 10:26pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 10:26pm ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 10:26pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 18 10:26pm ET |
| Started | WR | Cooper Kupp SEA | Owner | Tue Nov 18 10:26pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 18 10:26pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 19 8:36pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 19 8:36pm ET |
| Started | RB | Emanuel Wilson GB | Owner | Wed Nov 19 8:36pm ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Wed Nov 19 8:36pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Thu Nov 20 3:22pm ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 20 3:22pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Nov 19 9:32pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 19 9:32pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Wed Nov 19 12:15pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 19 12:15pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 18 6:51pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 6:51pm ET |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 6:51pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 18 6:51pm ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 18 6:51pm ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 18 6:51pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 18 6:51pm ET |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 18 6:51pm ET |
| No starting lineup changes performed this week. |
| Started | D/ST | Detroit Lions DET | Owner | Thu Nov 20 1:13pm ET |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 18 10:21am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 18 10:21am ET |
| Started | QB | Caleb Williams CHI | Owner | Tue Nov 18 10:21am ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 10:21am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Thu Nov 20 4:55pm ET |
| Started | TE | George Kittle SF | Owner | Thu Nov 20 4:55pm ET |
| Started | QB | Kirk Cousins ATL | Owner | Thu Nov 20 4:54pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 20 4:54pm ET |