

| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 8:36am ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 4 8:36am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 8:36am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 8:36am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 8:36am ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 4 8:36am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 9:51pm ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 9:51pm ET |
| Started | QB | Dillon Gabriel CLE | Owner | Tue Nov 4 9:51pm ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 9:51pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 4 9:58pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 4 9:58pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 9:58pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 9:58pm ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:58pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 9:58pm ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 6:08pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 4 6:08pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 12:42pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 12:42pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 4 12:42pm ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 4 12:42pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 4 12:42pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 11:01am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 11:01am ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 11:01am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 11:01am ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Tue Nov 4 8:53pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 8:53pm ET |
| Started | WR | Marvin Mims DEN | Owner | Tue Nov 4 8:53pm ET |
| No starting lineup changes performed this week. |