

| Benched | QB | C.J. Stroud HOU | Owner | Thu Nov 27 12:14pm ET |
| Started | QB | Jordan Love GB | Owner | Thu Nov 27 12:14pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 10:20am ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 10:19am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 10:19am ET |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 10:19am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 10:19am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 10:19am ET |
| Started | TE | Mike Gesicki CIN | Owner | Thu Nov 27 9:00am ET |
| Benched | TE | Brock Wright DET | Owner | Wed Nov 26 11:45pm ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Tue Nov 25 4:20pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 4:20pm ET |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 25 4:20pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:20pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Thu Nov 27 4:11am ET |
| Started | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 4:11am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 4:08am ET |
| Started | RB | Tony Pollard TEN | Owner | Thu Nov 27 4:08am ET |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 11:54am ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 11:54am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 11:54am ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 11:54am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Fri Nov 28 1:27pm ET |
| Started | TE | George Kittle SF | Owner | Fri Nov 28 1:27pm ET |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 2:40pm ET |
| Benched | TE | George Kittle SF | Owner | Tue Nov 25 2:40pm ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 2:40pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 2:40pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 10:17pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:17pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 10:13pm ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 25 10:13pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 25 5:23pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 5:23pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 5:23pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:23pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:23pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 5:23pm ET |
| Benched | RB | Breece Hall NYJ | Owner | Sun Nov 30 8:54am ET |
| Started | RB | Michael Carter ARI | Owner | Sun Nov 30 8:54am ET |
| Started | WR | Brian Thomas Jr. JAX | system | Sun Nov 30 6:26am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 1:13am ET |
| Benched | RB | Devin Neal NO | Owner | Sat Nov 29 1:13am ET |
| Started | RB | D'Andre Swift CHI | Owner | Fri Nov 28 2:48pm ET |
| Benched | WR | Parker Washington JAX | Owner | Fri Nov 28 2:48pm ET |
| Started | WR | Parker Washington JAX | Owner | Thu Nov 27 6:01pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 6:01pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 2:38pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 2:38pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 9:44pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 9:44pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:44pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:44pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 9:44pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 9:44pm ET |
| Started | WR | Darius Slayton NYG | Owner | Sun Nov 30 9:29am ET |
| Benched | WR | Greg Dortch ARI | Owner | Sun Nov 30 9:29am ET |
| Started | WR | DeVonta Smith PHI | Owner | Fri Nov 28 9:18am ET |
| Benched | WR | Darius Slayton NYG | Owner | Fri Nov 28 9:18am ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 8:09am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 8:09am ET |
| Started | WR | Cedric Tillman CLE | Owner | Wed Nov 26 5:09pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:09pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 5:09pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 5:09pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Wed Nov 26 5:09pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 4:05pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 4:05pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 4:05pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 4:05pm ET |
| No starting lineup changes performed this week. |