

| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 12:32am ET |
| Started | RB | Travis Etienne JAX | Owner | Wed Nov 26 11:22pm ET |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 26 11:22pm ET |
| Benched | WR | Davante Adams LAR | Owner | Tue Nov 25 10:49pm ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 25 10:49pm ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 25 10:49pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 10:49pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 7:41am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 4:25pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 4:25pm ET |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 8:38pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 8:38pm ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 8:38pm ET |
| Benched | K | Joey Slye TEN | Owner | Thu Nov 27 8:38pm ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 8:38pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 8:38pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 8:38pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 8:38pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 4:15pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:15pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 4:15pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 4:15pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Fri Nov 28 10:28am ET |
| Started | RB | Jeremy McNichols WAS | Owner | Fri Nov 28 10:28am ET |
| Benched | TE | Theo Johnson NYG | Owner | Fri Nov 28 10:26am ET |
| Started | TE | Gunnar Helm TEN | Owner | Fri Nov 28 10:26am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 7:25pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 7:25pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Fri Nov 28 9:52am ET |
| Started | RB | Zach Charbonnet SEA | Owner | Fri Nov 28 9:52am ET |
| Benched | TE | Luke Musgrave GB | Owner | Wed Nov 26 6:30am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 6:30am ET |
| Started | TE | Jonnu Smith PIT | Owner | Wed Nov 26 6:30am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 6:30am ET |
| No starting lineup changes performed this week. |
| Started | TE | Jake Ferguson DAL | Owner | Thu Nov 27 12:45pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:45pm ET |
| Started | QB | Drake Maye NE | Owner | Wed Nov 26 9:43am ET |
| Benched | QB | Josh Allen BUF | Owner | Wed Nov 26 9:43am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 9:43am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 9:43am ET |
| Started | QB | Josh Allen BUF | Owner | Wed Nov 26 9:43am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 9:43am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 9:43am ET |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 26 9:43am ET |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 2:33am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 2:33am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 2:33am ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:33am ET |