

| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 3:35pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 3:35pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 8:14am CT |
| Started | WR | Jauan Jennings SF | Owner | Thu Nov 27 8:14am CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 3:54pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:54pm CT |
| Benched | WR | Keon Coleman BUF | Owner | Wed Nov 26 12:44pm CT |
| Benched | WR | Josh Palmer BUF | Owner | Wed Nov 26 12:44pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 12:44pm CT |
| Started | WR | Marvin Mims DEN | Owner | Wed Nov 26 12:44pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 8:23am CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 8:23am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 6:23am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 6:23am CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 6:23am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:23am CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 6:17pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Wed Nov 26 6:17pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 6:17pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 6:17pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 6:08pm CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 6:08pm CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 6:36pm CT |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 6:36pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 6:36pm CT |
| Started | WR | Luther Burden III CHI | Owner | Thu Nov 27 6:36pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 6:36pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 11:12pm CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 11:12pm CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 11:12pm CT |
| Benched | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 11:06am CT |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 11:06am CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 11:06am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 11:06am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:06am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 11:06am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 9:54pm CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 11:15am CT |
| Started | QB | Max Brosmer MIN | Owner | Thu Nov 27 11:15am CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Thu Nov 27 11:15am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 8:38pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 8:38pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 8:38pm CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 8:38pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Wed Nov 26 8:38pm CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 8:38pm CT |
| Benched | WR | Khalil Shakir BUF | Owner | Wed Nov 26 8:38pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 8:38pm CT |
| Benched | RB | Tank Bigsby PHI | Owner | Wed Nov 26 8:38pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 8:38pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 1:04pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 1:04pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:27pm CT |
| Started | QB | Geno Smith LV | Owner | Tue Nov 25 5:27pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 8:19am CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 8:19am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:19am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:19am CT |
| Started | WR | Kayshon Boutte NE | Owner | Tue Nov 25 8:19am CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 25 8:19am CT |