

| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 4:12pm ET |
| Started | QB | Geno Smith LV | Owner | Tue Nov 25 4:12pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 4:11pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 4:11pm ET |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 12:12pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 12:12pm ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 12:12pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 12:12pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 12:12pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:12pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 4:27pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 4:27pm ET |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 6:43pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 6:43pm ET |
| Benched | RB | Jerome Ford CLE | Owner | Tue Nov 25 6:16pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 6:16pm ET |
| Benched | QB | Russell Wilson NYG | Owner | Tue Nov 25 6:16pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 6:16pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 4:57pm ET |
| Benched | WR | Van Jefferson TEN | Owner | Tue Nov 25 4:57pm ET |
| Benched | WR | Josh Palmer BUF | Owner | Tue Nov 25 4:57pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 4:57pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 4:57pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 4:57pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 10:18am ET |
| Started | RB | Kimani Vidal LAC | Owner | Thu Nov 27 10:18am ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 10:52am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 10:52am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 10:52am ET |
| Benched | RB | Bucky Irving TB | Owner | Fri Nov 28 12:31pm ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Fri Nov 28 12:31pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Fri Nov 28 12:28pm ET |
| Started | TE | Evan Engram DEN | Owner | Fri Nov 28 12:28pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Fri Nov 28 12:28pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Fri Nov 28 12:28pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 12:50pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 12:50pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 7:39am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 7:39am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:39am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 7:39am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Bryce Young CAR | Owner | Sun Nov 30 7:14am ET |
| Started | QB | Baker Mayfield TB | Owner | Sun Nov 30 7:14am ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 8:29am ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 8:29am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:29am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:29am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Nov 26 8:29am ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 8:29am ET |