

| Benched | WR | Terry McLaurin WAS | Owner | Tue Nov 25 8:09am ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 8:09am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 8:08am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:08am ET |
| Benched | K | Matt Prater BUF | Owner | Tue Nov 25 8:08am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 8:08am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 8:08am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 8:08am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 7:48am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 7:48am ET |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 7:37am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 7:37am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 6:13pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 6:13pm ET |
| Benched | WR | Michael Wilson ARI | Owner | Tue Nov 25 11:20am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 11:20am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 11:14am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:14am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 11:14am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 11:14am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:14am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 11:14am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |