

| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 5 12:28am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 5 12:28am ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 5 12:28am ET |
| Started | RB | Alvin Kamara NO | Owner | Wed Nov 5 12:28am ET |
| Started | RB | Jordan Mason MIN | Owner | Wed Nov 5 12:28am ET |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 12:28am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 11:01pm ET |
| Benched | RB | Jaydon Blue DAL | Owner | Tue Nov 4 11:01pm ET |
| Started | RB | Tank Bigsby PHI | Owner | Tue Nov 4 11:01pm ET |
| Started | WR | Josh Downs IND | Owner | Tue Nov 4 11:01pm ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 8:34am ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 4 8:34am ET |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 9:45am ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 4 9:45am ET |
| Benched | WR | Tre Harris LAC | Owner | Tue Nov 4 9:45am ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 4 9:45am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 4 10:00pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 10:00pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 4 10:00pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 10:00pm ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 10:00pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 10:00pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 7:21am ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 7:21am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 7:21am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 7:21am ET |
| Started | WR | Dyami Brown JAX | Owner | Tue Nov 4 7:21am ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 4 7:21am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 8:47am ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 8:47am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 4 6:11pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 6:11pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 4 12:48pm ET |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 4 12:48pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 12:47pm ET |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 4 12:47pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 12:47pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 12:47pm ET |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 4 12:47pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:34am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 7:34am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 4 7:33am ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 7:33am ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:33am ET |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 7:33am ET |
| Benched | WR | Elic Ayomanor TEN | Owner | Tue Nov 4 7:32am ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:32am ET |
| No starting lineup changes performed this week. |
| Started | QB | Jayden Daniels WAS | Owner | Tue Nov 4 9:20pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 9:18pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 9:17pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 9:11am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 4 9:11am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:11am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 9:11am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 9:11am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 9:11am ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 9:11am ET |