

| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 4:03pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 4:03pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 4:03pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 4:03pm CT |
| Started | RB | Michael Carter ARI | Owner | Wed Nov 26 11:33pm CT |
| Benched | RB | Ty Johnson BUF | Owner | Wed Nov 26 11:33pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 8:46am CT |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 8:46am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:46am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:46am CT |
| Started | RB | Ty Johnson BUF | Owner | Wed Nov 26 8:46am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:46am CT |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 8:46am CT |
| Benched | WR | Matthew Golden GB | Owner | Wed Nov 26 8:46am CT |
| Benched | RB | Trevor Etienne CAR | Owner | Wed Nov 26 8:46am CT |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 8:46am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sun Nov 30 11:53am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 11:53am CT |
| Benched | WR | Khalil Shakir BUF | Owner | Sun Nov 30 11:53am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Sun Nov 30 11:53am CT |
| Started | RB | Tahj Brooks CIN | Owner | Thu Nov 27 6:49pm CT |
| Benched | RB | Keaton Mitchell BAL | Owner | Thu Nov 27 6:49pm CT |
| Started | RB | Keaton Mitchell BAL | Owner | Wed Nov 26 7:10pm CT |
| Benched | RB | Justice Hill BAL | Owner | Wed Nov 26 7:10pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 3:00pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 3:00pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 2:59pm CT |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Nov 26 2:59pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 2:59pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 2:59pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 2:13pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 2:13pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 9:59pm CT |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 9:59pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 8:16am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:16am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 8:16am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:16am CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 8:16am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 8:16am CT |
| Benched | WR | Demario Douglas NE | Owner | Tue Nov 25 8:16am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 8:16am CT |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 10:22am CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 10:22am CT |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 7:09pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 7:09pm CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 7:29am CT |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 7:29am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:29am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 7:29am CT |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 7:41pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 7:41pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 7:41pm CT |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 7:41pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 6:07pm CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 6:07pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:07pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:07pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 6:50pm CT |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 6:50pm CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 6:50pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 6:50pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Wed Nov 26 3:07pm CT |
| Started | RB | Kareem Hunt KC | Owner | Wed Nov 26 3:07pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:34pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 11:34pm CT |
| Started | WR | Xavier Legette CAR | Owner | Tue Nov 25 11:34pm CT |
| Started | WR | John Metchie III NYJ | Owner | Tue Nov 25 11:34pm CT |