

| Benched | RB | Devin Singletary NYG | Owner | Sat Nov 29 2:50pm CT |
| Started | RB | Tyjae Spears TEN | Owner | Sat Nov 29 2:50pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 6:59pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 6:59pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:59pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:59pm CT |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 6:59pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:59pm CT |
| Benched | WR | Cooper Kupp SEA | Owner | Fri Nov 28 7:51pm CT |
| Started | WR | Greg Dortch ARI | Owner | Fri Nov 28 7:51pm CT |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Nov 27 3:27pm CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:27pm CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 3:42pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:42pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 25 4:06pm CT |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 4:06pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 4:06pm CT |
| Started | RB | Dylan Sampson CLE | Owner | Tue Nov 25 4:06pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 4:15pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 4:15pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 4:15pm CT |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 4:15pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 4:15pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 4:15pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 4:15pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 4:15pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 12:46am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 12:46am CT |
| Benched | WR | Demario Douglas NE | Owner | Thu Nov 27 12:46am CT |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Thu Nov 27 12:46am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 12:46am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 12:46am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Breece Hall NYJ | Owner | Thu Nov 27 4:59pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 4:59pm CT |
| Started | RB | Travis Etienne JAX | Owner | Thu Nov 27 4:59pm CT |
| Started | WR | Chris Olave NO | Owner | Thu Nov 27 4:59pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 5:13pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:13pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 5:12pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 5:12pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 5:12pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 5:12pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:39pm CT |
| Started | RB | Kyle Monangai CHI | Owner | Wed Nov 26 10:39pm CT |