

| No starting lineup changes performed this week. |
| Benched | WR | Alec Pierce IND | Owner | Sun Nov 30 11:23am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 11:23am CT |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 5:49am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 5:49am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 11:09am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 11:09am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 4:59pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 4:59pm CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Fri Nov 28 2:02pm CT |
| Started | RB | Kenneth Walker III SEA | Owner | Fri Nov 28 2:02pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 4:11pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:11pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 4:11pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 26 4:11pm CT |
| Benched | K | Andres Borregales NE | Owner | Wed Nov 26 3:35pm CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 3:35pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 9:46pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:46pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 1:52pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 1:52pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:52pm CT |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 1:52pm CT |
| Benched | QB | Geno Smith LV | Owner | Sun Nov 30 7:30am CT |
| Started | QB | Aaron Rodgers PIT | Owner | Sun Nov 30 7:30am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Parker Washington JAX | Owner | Thu Nov 27 7:18am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 7:18am CT |
| Benched | RB | Omarion Hampton LAC | Owner | Thu Nov 27 7:15am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 7:15am CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 11:18am CT |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 11:18am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:43pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 10:43pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 10:43pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 10:43pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 6:14am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 6:14am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 3:52am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 3:52am CT |