

| No starting lineup changes performed this week. |
| Benched | QB | Dak Prescott DAL | Owner | Sat Dec 13 11:01am ET |
| Started | QB | Jaxson Dart NYG | Owner | Sat Dec 13 11:01am ET |
| Started | TE | Evan Engram DEN | Owner | Sat Dec 13 11:01am ET |
| Started | TE | Juwan Johnson NO | Owner | Sun Dec 14 10:32am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Sun Dec 14 10:32am ET |
| Started | TE | George Kittle SF | Owner | Thu Dec 11 12:55pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Dec 11 12:55pm ET |
| Started | WR | Stefon Diggs NE | Owner | Thu Dec 11 12:55pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Thu Dec 11 12:55pm ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Dec 11 12:55pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Thu Dec 11 12:55pm ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Dec 11 12:55pm ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Thu Dec 11 12:55pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Thu Dec 11 12:55pm ET |
| Benched | QB | Bo Nix DEN | Owner | Thu Dec 11 12:55pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Dec 10 8:47pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Dec 10 8:47pm ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Dec 10 8:46pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Dec 10 8:46pm ET |
| Benched | QB | Jalen Hurts PHI | Owner | Wed Dec 10 8:37pm ET |
| Started | QB | Drake Maye NE | Owner | Wed Dec 10 8:37pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Dec 9 7:58pm ET |
| Benched | K | Tyler Loop BAL | Owner | Tue Dec 9 7:58pm ET |
| Started | WR | Chris Godwin TB | Owner | Tue Dec 9 7:58pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Dec 9 7:58pm ET |
| Benched | QB | Jayden Daniels WAS | Owner | Wed Dec 10 2:05pm ET |
| Started | QB | Sam Darnold SEA | Owner | Wed Dec 10 2:05pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Wed Dec 10 2:04pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Dec 10 2:04pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Dec 11 3:03am ET |
| Benched | D/ST | New Orleans Saints NO | Owner | Tue Dec 9 10:16am ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Dec 9 10:16am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Dalton Schultz HOU | Owner | Fri Dec 12 10:21pm ET |
| Started | TE | Theo Johnson NYG | Owner | Fri Dec 12 10:21pm ET |
| Started | D/ST | New England Patriots NE | Owner | Thu Dec 11 6:50pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Dec 9 8:42pm ET |
| Benched | WR | Devaughn Vele NO | Owner | Tue Dec 9 8:42pm ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Tue Dec 9 8:42pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Dec 9 8:42pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Romeo Doubs GB | Owner | Tue Dec 9 1:20pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Dec 9 1:20pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Tue Dec 9 1:20pm ET |
| Started | WR | Rome Odunze CHI | Owner | Tue Dec 9 1:20pm ET |
| No starting lineup changes performed this week. |