

| No starting lineup changes performed this week. |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 6:49am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 6:49am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 12:09pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 12:09pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 5:59pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 5:59pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Fri Nov 28 3:02pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Fri Nov 28 3:02pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 5:11pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 5:11pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 5:11pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 26 5:11pm ET |
| Benched | K | Andres Borregales NE | Owner | Wed Nov 26 4:35pm ET |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 4:35pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 10:46pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 10:46pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 2:52pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 2:52pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 2:52pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 2:52pm ET |
| Benched | QB | Geno Smith LV | Owner | Sun Nov 30 8:30am ET |
| Started | QB | Aaron Rodgers PIT | Owner | Sun Nov 30 8:30am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Parker Washington JAX | Owner | Thu Nov 27 8:18am ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 8:18am ET |
| Benched | RB | Omarion Hampton LAC | Owner | Thu Nov 27 8:15am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 8:15am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 12:18pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 12:18pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 11:43pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 11:43pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 11:43pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 11:43pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 7:14am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 7:14am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 4:52am ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 4:52am ET |