

| Benched | QB | Jameis Winston NYG | Owner | Sun Nov 30 8:43am CT |
| Started | QB | Baker Mayfield TB | Owner | Sun Nov 30 8:43am CT |
| Benched | RB | Sean Tucker TB | Owner | Sun Nov 30 8:40am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Sun Nov 30 8:40am CT |
| Started | QB | Jameis Winston NYG | Owner | Sun Nov 30 8:35am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 7:30pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:30pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 8:47am CT |
| Benched | RB | Ashton Jeanty LV | Owner | Tue Nov 25 8:05pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:05pm CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 3:36am CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 3:36am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 10:13pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 10:13pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 10:13pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 10:13pm CT |
| Started | RB | Rachaad White TB | Owner | Sat Nov 29 10:12pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Sat Nov 29 10:12pm CT |
| Started | RB | Zach Charbonnet SEA | Owner | Sat Nov 29 10:03pm CT |
| Benched | RB | Rachaad White TB | Owner | Sat Nov 29 10:03pm CT |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 26 10:27pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Wed Nov 26 10:27pm CT |
| Started | TE | Colston Loveland CHI | Owner | Wed Nov 26 2:33pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Wed Nov 26 2:33pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 2:21pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 2:21pm CT |
| Started | RB | Rachaad White TB | Owner | Tue Nov 25 2:19pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 2:19pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Tue Nov 25 2:18pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 2:18pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 11:39am CT |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 26 5:14pm CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 26 5:14pm CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 6:34am CT |
| Started | TE | Hunter Henry NE | Owner | Thu Nov 27 6:34am CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 25 10:03am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Nov 25 10:01am CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 10:01am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 10:01am CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 7:21am CT |
| Benched | TE | Brenton Strange JAX | Owner | Wed Nov 26 7:21am CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 7:21am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 7:21am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 6:15pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 6:15pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:15pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:15pm CT |
| Benched | RB | Nick Chubb HOU | Owner | Wed Nov 26 8:53pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 8:53pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Wed Nov 26 8:53pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Wed Nov 26 8:53pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:53pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 8:53pm CT |
| Started | TE | Pat Freiermuth PIT | Owner | Sat Nov 29 11:07pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 6:15pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 6:15pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 9:13pm CT |
| Benched | K | Harrison Butker KC | Owner | Wed Nov 26 9:13pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 9:13pm CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 9:13pm CT |
| No starting lineup changes performed this week. |