

| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 3:41pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:41pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 10:59am CT |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 10:59am CT |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 10:59am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 10:59am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 10:59am CT |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 10:59am CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 11:49am CT |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 11:49am CT |
| Benched | WR | Romeo Doubs GB | Owner | Thu Nov 27 11:49am CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 11:49am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 11:49am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 11:49am CT |
| Benched | QB | Tyler Shough NO | Owner | Thu Nov 27 5:25am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 5:25am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 1:59pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 1:59pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 1:59pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 1:59pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Kendrick Bourne SF | Owner | Thu Nov 27 2:19pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 2:19pm CT |
| Benched | WR | Chris Olave NO | Owner | Wed Nov 26 11:43pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 11:43pm CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Wed Nov 26 9:01am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:01am CT |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 10:27am CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:27am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 10:27am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:27am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 10:27am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 10:27am CT |
| No starting lineup changes performed this week. |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sat Nov 29 9:58pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Thu Nov 27 6:08am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 6:08am CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 5:23pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:23pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:23pm CT |
| Benched | WR | Van Jefferson TEN | Owner | Tue Nov 25 5:23pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 5:23pm CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 5:23pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 25 5:23pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 5:22pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 5:22pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 5:22pm CT |
| Started | QB | Geno Smith LV | Owner | Tue Nov 25 5:22pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 5:22pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:22pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Fri Nov 28 8:15am CT |
| Started | WR | Tez Johnson TB | Owner | Fri Nov 28 8:15am CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 6:05pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:05pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:42am CT |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 9:42am CT |