

| No starting lineup changes performed this week. |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 10:13am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 10:13am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Sun Nov 30 12:43pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sun Nov 30 12:43pm ET |
| Benched | WR | Sterling Shepard TB | Owner | Thu Nov 27 1:13pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 1:13pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | New Orleans Saints NO | Owner | Thu Nov 27 12:06am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 12:06am ET |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 12:05am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:05am ET |
| Benched | WR | Darius Slayton NYG | Owner | Thu Nov 27 4:22pm ET |
| Started | WR | Chimere Dike TEN | Owner | Thu Nov 27 4:22pm ET |
| Benched | WR | Malik Washington MIA | Owner | Wed Nov 26 1:06pm ET |
| Started | WR | Marquise Brown KC | Owner | Wed Nov 26 1:06pm ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 9:17pm ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 9:17pm ET |
| Started | RB | Dylan Sampson CLE | Owner | Fri Nov 28 8:42pm ET |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 8:42pm ET |
| Started | WR | Alec Pierce IND | Owner | Thu Nov 27 4:10pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 4:10pm ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 4:09pm ET |
| Benched | TE | Jonnu Smith PIT | Owner | Thu Nov 27 4:09pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 4:08pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 6:08pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 6:08pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 6:08pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Wed Nov 26 6:08pm ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 6:08pm ET |
| Benched | WR | Jalen Nailor MIN | Owner | Wed Nov 26 6:08pm ET |
| Benched | WR | Xavier Hutchinson HOU | Owner | Wed Nov 26 6:08pm ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 6:08pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 11:46am ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 11:46am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 11:46am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 11:46am ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Sun Nov 30 12:26pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Sun Nov 30 12:26pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Wed Nov 26 5:52pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Wed Nov 26 5:52pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 5:46pm ET |
| Started | WR | Mack Hollins NE | Owner | Wed Nov 26 5:46pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 5:23pm ET |
| Started | WR | Greg Dortch ARI | Owner | Wed Nov 26 5:23pm ET |
| No starting lineup changes performed this week. |
| Benched | K | Cam Little JAX | Owner | Wed Nov 26 2:28am ET |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 2:28am ET |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Nov 26 2:27am ET |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 2:27am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 11:35am ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 11:35am ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 12:29am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 12:29am ET |
| Started | QB | Jaxson Dart NYG | Owner | Thu Nov 27 12:29am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 12:29am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:07pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Thu Nov 27 12:06pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Thu Nov 27 12:06pm ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 12:06pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 12:06pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 10:35am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 10:35am ET |
| Started | RB | Isaiah Davis NYJ | Owner | Thu Nov 27 10:35am ET |
| Started | WR | Calvin Austin III PIT | Owner | Thu Nov 27 10:35am ET |