

| No starting lineup changes performed this week. |
| Benched | D/ST | New England Patriots NE | Owner | Thu Nov 20 10:06am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 20 10:06am ET |
| Benched | RB | Terrell Jennings NE | Owner | Wed Nov 19 4:31am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 19 4:31am ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 19 4:31am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 19 4:31am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Denver Broncos DEN | Owner | Thu Nov 20 4:39pm ET |
| Started | D/ST | New Orleans Saints NO | Owner | Thu Nov 20 4:39pm ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 20 4:38pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Thu Nov 20 4:38pm ET |
| Started | RB | Chase Brown CIN | Owner | Thu Nov 20 4:38pm ET |
| Started | WR | Chris Olave NO | Owner | Thu Nov 20 4:38pm ET |
| Benched | WR | Malik Washington MIA | Owner | Tue Nov 18 12:20pm ET |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 18 12:20pm ET |
| Started | RB | Michael Carter ARI | Owner | Thu Nov 20 12:20pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 12:29pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 12:29pm ET |
| Started | WR | Xavier Hutchinson HOU | Owner | Tue Nov 18 12:29pm ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 18 12:29pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 20 10:19am ET |
| Started | WR | Kayshon Boutte NE | Owner | Thu Nov 20 10:19am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 10:53am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 10:53am ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 10:53am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 18 10:53am ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 18 10:34pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 18 10:34pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 18 10:34pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 18 10:34pm ET |
| No starting lineup changes performed this week. |
| Benched | K | Cameron Dicker LAC | Owner | Thu Nov 20 10:50am ET |
| Started | K | Cam Little JAX | Owner | Thu Nov 20 10:50am ET |
| Benched | WR | Troy Franklin DEN | Owner | Thu Nov 20 10:48am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 20 10:48am ET |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 9:54am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 18 9:54am ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Thu Nov 20 12:31am ET |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 20 12:31am ET |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 19 8:53am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 19 8:53am ET |
| Benched | TE | Zach Ertz WAS | Owner | Wed Nov 19 8:53am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 19 8:53am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 19 8:53am ET |
| Started | TE | Juwan Johnson NO | Owner | Wed Nov 19 8:53am ET |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 1:26pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 18 1:26pm ET |
| Started | WR | Xavier Legette CAR | Owner | Tue Nov 18 1:26pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 1:26pm ET |
| No starting lineup changes performed this week. |