

| Started | RB | Ashton Jeanty LV | Owner | Fri Nov 28 6:55pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Fri Nov 28 6:55pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Fri Nov 28 6:55pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Fri Nov 28 6:55pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 10:40am ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 10:40am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 2:54pm ET |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Nov 26 2:54pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 9:50am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 9:50am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:50am ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 9:50am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Dylan Sampson CLE | Owner | Thu Nov 27 8:46am ET |
| Started | WR | Tez Johnson TB | Owner | Thu Nov 27 8:46am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 9:20am ET |
| Benched | WR | Devaughn Vele NO | Owner | Tue Nov 25 9:20am ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 9:20am ET |
| Started | RB | Dylan Sampson CLE | Owner | Tue Nov 25 9:20am ET |
| Benched | RB | Michael Carter ARI | Owner | Wed Nov 26 5:59pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 5:59pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 11:16pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 11:16pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 10:49pm ET |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 10:49pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:01pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 8:01pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 25 8:01pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 8:01pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:01pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:01pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 12:14pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Wed Nov 26 12:14pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Wed Nov 26 12:14pm ET |
| Started | WR | Josh Downs IND | Owner | Wed Nov 26 12:14pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 12:14pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 12:14pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 9:16am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:16am ET |