

| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 10:24pm CT |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 6:51pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 6:51pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 6:51pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:51pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 6:51pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 4:16pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 4:16pm CT |
| Started | WR | Troy Franklin DEN | Owner | Sun Nov 30 9:44am CT |
| Benched | RB | Blake Corum LAR | Owner | Sun Nov 30 9:44am CT |
| Started | RB | Blake Corum LAR | Owner | Sun Nov 30 9:44am CT |
| Benched | WR | Troy Franklin DEN | Owner | Sun Nov 30 9:44am CT |
| Started | WR | Chimere Dike TEN | Owner | Sun Nov 30 9:44am CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Sun Nov 30 9:44am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 9:43am CT |
| Benched | WR | Chimere Dike TEN | Owner | Sun Nov 30 9:43am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 8:13pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 8:13pm CT |
| Started | QB | Josh Allen BUF | Owner | Tue Nov 25 8:13pm CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 8:13pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:13pm CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 8:13pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:11pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 8:11pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 8:11pm CT |
| Benched | QB | Josh Allen BUF | Owner | Tue Nov 25 8:11pm CT |
| Benched | QB | J.J. McCarthy MIN | system | Sun Nov 30 5:25am CT |
| Started | RB | Devon Achane MIA | system | Sun Nov 30 5:25am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Sun Nov 30 9:53am CT |
| Started | WR | Quentin Johnston LAC | Owner | Sun Nov 30 9:53am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Thu Nov 27 6:38pm CT |
| Benched | WR | Khalil Shakir BUF | Owner | Thu Nov 27 6:38pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 6:38pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 6:38pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Sat Nov 29 1:27pm CT |
| Started | QB | Max Brosmer MIN | Owner | Sat Nov 29 1:27pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 4:43pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 4:43pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 4:43pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 4:43pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 2:24pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:24pm CT |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 5:50am CT |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 5:50am CT |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 5:49am CT |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 5:49am CT |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 10:38pm CT |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 25 10:38pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 6:53am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 6:53am CT |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 6:53am CT |
| Started | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 6:53am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:53am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 6:53am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sat Nov 29 1:52pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Sat Nov 29 1:52pm CT |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 9:11am CT |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 9:11am CT |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 9:10am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:10am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Nov 25 9:10am CT |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 25 9:10am CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 9:10am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 25 9:10am CT |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 9:10am CT |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 6:14am CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Nov 25 6:14am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 6:14am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 6:14am CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 6:14am CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 25 6:14am CT |
| Benched | WR | Amon-Ra St. Brown DET | Owner | Tue Nov 25 6:14am CT |
| Benched | TE | Gunnar Helm TEN | Owner | Tue Nov 25 6:14am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 6:14am CT |