

| Benched | QB | Dillon Gabriel CLE | Owner | Tue Nov 25 2:37pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 2:37pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 5:10pm ET |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 5:10pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 5:10pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:10pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 5:10pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 5:10pm ET |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 7:51pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:51pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:51pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 7:51pm ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Sat Nov 29 8:57pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 5:12pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 5:12pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Wed Nov 26 4:41pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 4:41pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 6:59pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 6:59pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 8:36pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 8:36pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:36pm ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 8:36pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Wed Nov 26 1:37am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 1:37am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 26 1:37am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 1:37am ET |
| Started | RB | Jeremy McNichols WAS | Owner | Wed Nov 26 1:37am ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 1:37am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Zach Charbonnet SEA | Owner | Fri Nov 28 8:52am ET |
| Started | WR | Parker Washington JAX | Owner | Fri Nov 28 8:52am ET |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 8:30pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:30pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 8:30pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:30pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:30pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 8:30pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Thu Nov 27 12:41am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 12:41am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:41am ET |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 27 12:41am ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 2:58pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:58pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 9:59am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:59am ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 3:31pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:31pm ET |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 9:11am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:11am ET |