

| No starting lineup changes performed this week. |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 9:34pm CT |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 9:34pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 7:07am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 7:07am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 6:22am CT |
| Benched | WR | Jaylin Noel HOU | Owner | Tue Nov 25 6:22am CT |
| Benched | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 6:22am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 6:22am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 6:22am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 6:22am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 7:44pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 7:44pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 6:42pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 6:42pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 6:40am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 10:13am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Fri Nov 28 8:22am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Fri Nov 28 8:22am CT |
| Benched | QB | Geno Smith LV | Owner | Fri Nov 28 8:21am CT |
| Started | QB | Bo Nix DEN | Owner | Fri Nov 28 8:21am CT |
| Benched | RB | Nick Chubb HOU | Owner | Thu Nov 27 9:58am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 9:58am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 9:58am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 9:58am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 9:58am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 9:58am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:37pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 26 10:37pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 10:37pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 10:37pm CT |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 3:56am CT |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 3:56am CT |
| Benched | WR | Michael Wilson ARI | Owner | Tue Nov 25 6:46am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:46am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 6:45am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 6:45am CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 6:11pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 6:11pm CT |
| Benched | K | Cairo Santos CHI | Owner | Tue Nov 25 6:11pm CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Tue Nov 25 6:11pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:11pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 6:11pm CT |
| Started | K | Harrison Butker KC | Owner | Tue Nov 25 6:11pm CT |
| Started | D/ST | Indianapolis Colts IND | Owner | Tue Nov 25 6:11pm CT |