

| Benched | TE | George Kittle SF | Owner | Sat Nov 29 6:54am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 6:54am ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 5:04pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 5:04pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 5:04pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:04pm ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 12:35pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 12:35pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 7:22pm ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 7:22pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 7:22pm ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 7:22pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 11:16am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:16am ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 10:09am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:09am ET |
| Started | QB | Cam Ward TEN | Owner | Wed Nov 26 10:09am ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 10:09am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 10:51pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 10:51pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 10:51pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 10:51pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:51pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 10:51pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 10:51pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 10:51pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 12:11pm ET |
| Started | WR | Darius Slayton NYG | Owner | Wed Nov 26 12:11pm ET |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 4:37pm ET |
| Started | RB | Devin Singletary NYG | Owner | Fri Nov 28 4:37pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Thu Nov 27 7:21am ET |
| Started | RB | Omarion Hampton LAC | Owner | Thu Nov 27 7:21am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 7:43am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 7:43am ET |
| Benched | QB | Kirk Cousins ATL | Owner | Thu Nov 27 11:18am ET |
| Benched | WR | John Metchie III NYJ | Owner | Thu Nov 27 11:18am ET |
| Benched | TE | Dallas Goedert PHI | Owner | Thu Nov 27 11:18am ET |
| Benched | TE | Brenton Strange JAX | Owner | Thu Nov 27 11:18am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 11:18am ET |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 27 11:18am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 11:18am ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 3:25pm ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 2:51pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 9:03am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 9:03am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 9:03am ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 25 9:03am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 9:03am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:03am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Wed Nov 26 10:55pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 10:55pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 8:36am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 8:36am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 8:36am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:36am ET |
| No starting lineup changes performed this week. |