

| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 9:49am ET |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 9:49am ET |
| Started | QB | Jaxson Dart NYG | Owner | Sat Nov 29 4:06pm ET |
| Benched | QB | Tua Tagovailoa MIA | Owner | Sat Nov 29 4:06pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Sat Nov 29 4:05pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Sat Nov 29 4:05pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 5:15pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Fri Nov 28 5:15pm ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:22am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:22am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 12:21am ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 12:21am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 2:44pm ET |
| Benched | WR | Zay Flowers BAL | Owner | Wed Nov 26 2:44pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Wed Nov 26 2:44pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 2:44pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:35am ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 9:35am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:34am ET |
| Benched | RB | Bucky Irving TB | Owner | Wed Nov 26 9:34am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 12:12am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 12:12am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 12:12am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 12:12am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 10:58pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 10:58pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 10:16am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 10:16am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 10:16am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 10:16am ET |
| Benched | WR | Jordan Addison MIN | Owner | Sun Nov 30 10:37am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Sun Nov 30 10:37am ET |
| Started | WR | Troy Franklin DEN | Owner | Sun Nov 30 10:37am ET |
| Started | WR | Adonai Mitchell NYJ | Owner | Sun Nov 30 10:37am ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:55am ET |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 9:55am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 9:04am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 9:04am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 8:14am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Thu Nov 27 8:14am ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 8:56pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 26 8:56pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:02pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:02pm ET |
| Started | RB | Emanuel Wilson GB | Owner | Tue Nov 25 11:55am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 11:55am ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:55am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 11:55am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 8:15am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:15am ET |
| Benched | D/ST | New Orleans Saints NO | Owner | Tue Nov 25 8:15am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 8:15am ET |
| Started | D/ST | Miami Dolphins MIA | Owner | Thu Nov 27 5:28am ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 7:54am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:54am ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 10:57pm ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 10:57pm ET |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 9:01am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 9:01am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:00am ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 9:00am ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 11:03pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:03pm ET |
| Benched | K | Michael Badgley IND | Owner | Tue Nov 25 11:03pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:03pm ET |
| Started | RB | Jeremy McNichols WAS | Owner | Tue Nov 25 11:03pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:03pm ET |