

| Benched | RB | Aaron Jones MIN | Owner | Fri Nov 28 8:43pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Fri Nov 28 8:43pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Thu Nov 27 4:25pm ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 4:25pm ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Fri Nov 28 5:21pm ET |
| Started | RB | Bucky Irving TB | Owner | Fri Nov 28 5:21pm ET |
| Benched | RB | Bucky Irving TB | Owner | Wed Nov 26 9:42am ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 9:42am ET |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 9:42am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:42am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:42am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:42am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 2:36pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 2:36pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 2:36pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 2:36pm ET |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 3:35pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Fri Nov 28 3:35pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 5:07pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 5:07pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 5:07pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:07pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 5:07pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 5:07pm ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 8:41am ET |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 8:41am ET |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 26 8:41am ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 8:41am ET |
| Benched | WR | Jameson Williams DET | Owner | Thu Nov 27 12:55am ET |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 12:55am ET |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 10:28pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 26 10:28pm ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 10:27pm ET |
| Benched | TE | Terrance Ferguson LAR | Owner | Wed Nov 26 10:27pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 10:27pm ET |
| Started | TE | Noah Fant CIN | Owner | Wed Nov 26 10:27pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Pat Freiermuth PIT | Owner | Thu Nov 27 3:18am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 3:18am ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Wed Nov 26 2:01am ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 2:01am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Wed Nov 26 2:01am ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 2:01am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 2:00am ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 2:00am ET |
| Benched | WR | Tez Johnson TB | Owner | Thu Nov 27 10:01pm ET |
| Started | WR | Jordan Addison MIN | Owner | Thu Nov 27 10:01pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 7:05am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 7:05am ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 7:05am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:05am ET |
| Benched | QB | Aaron Rodgers PIT | Owner | Fri Nov 28 10:02am ET |
| Benched | WR | Gabriel Davis BUF | Owner | Fri Nov 28 10:02am ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Fri Nov 28 10:02am ET |
| Started | QB | Cam Ward TEN | Owner | Fri Nov 28 10:02am ET |
| Started | WR | Kayshon Boutte NE | Owner | Fri Nov 28 10:02am ET |
| Started | WR | Troy Franklin DEN | Owner | Fri Nov 28 10:02am ET |
| Benched | RB | Sean Tucker TB | Owner | Sun Nov 30 11:45am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 11:45am ET |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 1:09am ET |
| Started | WR | Chimere Dike TEN | Owner | Wed Nov 26 1:09am ET |
| Started | RB | Devin Neal NO | Owner | Sun Nov 30 9:36am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Sun Nov 30 9:36am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Fri Nov 28 1:35pm ET |
| Benched | RB | Devin Neal NO | Owner | Fri Nov 28 1:35pm ET |
| Started | QB | Baker Mayfield TB | Owner | Fri Nov 28 1:35pm ET |
| Benched | QB | Geno Smith LV | Owner | Fri Nov 28 1:35pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 7:29pm ET |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 7:29pm ET |
| Started | QB | Geno Smith LV | Owner | Wed Nov 26 9:54am ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 9:54am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 10:51am ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 10:51am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 10:51am ET |
| Benched | RB | Devin Neal NO | Owner | Tue Nov 25 10:51am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 10:50am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 10:50am ET |
| Started | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 10:50am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:50am ET |