

| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 25 3:50pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 3:50pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 3:50pm CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 3:50pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:50pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:50pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 6:51am CT |
| Started | RB | Zach Charbonnet SEA | Owner | Thu Nov 27 6:51am CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 9:07pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:07pm CT |
| Started | RB | Ty Johnson BUF | Owner | Thu Nov 27 7:36am CT |
| Benched | RB | Ty Johnson BUF | Owner | Tue Nov 25 12:29pm CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 12:28pm CT |
| Started | RB | Ty Johnson BUF | Owner | Tue Nov 25 12:28pm CT |
| Started | WR | Cedric Tillman CLE | Owner | Tue Nov 25 12:28pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 12:27pm CT |
| Benched | WR | Darius Slayton NYG | Owner | Tue Nov 25 12:27pm CT |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 25 12:27pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 1:28pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 1:28pm CT |
| Started | RB | Kyle Monangai CHI | Owner | Thu Nov 27 9:54am CT |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 9:54am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 9:53am CT |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 9:53am CT |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 9:53am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 9:53am CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 7:29pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 7:29pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 7:29pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:29pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 9:35am CT |
| Benched | WR | Sterling Shepard TB | Owner | Tue Nov 25 9:35am CT |
| Started | RB | Woody Marks HOU | Owner | Tue Nov 25 9:34am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 25 9:34am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 9:34am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:34am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:34am CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 9:34am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 9:34am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 9:34am CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 5:51pm CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 5:51pm CT |
| Benched | WR | Xavier Legette CAR | Owner | Tue Nov 25 5:48pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 5:48pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 3:28pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Wed Nov 26 3:28pm CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 3:28pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 3:28pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 3:28pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 3:28pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 7:42am CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 7:42am CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 8:32am CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 25 8:32am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:32am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:32am CT |
| Benched | WR | D.J. Moore CHI | Owner | Fri Nov 28 1:55pm CT |
| Started | WR | Jakobi Meyers JAX | Owner | Fri Nov 28 1:55pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 2:21pm CT |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 2:21pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 2:21pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 2:21pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 2:21pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 2:21pm CT |