

| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 10:59am ET |
| Benched | WR | Matthew Golden GB | Owner | Thu Nov 27 10:59am ET |
| Started | RB | Kimani Vidal LAC | Owner | Thu Nov 27 10:59am ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 10:59am ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 4:54pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 4:54pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 25 4:54pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 4:54pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 7:03pm ET |
| Started | WR | Chris Godwin TB | Owner | Wed Nov 26 7:03pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 12:40pm ET |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 12:40pm ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 1:45am ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 1:45am ET |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 27 1:45am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 1:45am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 1:45am ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 1:45am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Colston Loveland CHI | Owner | Tue Nov 25 9:23pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:23pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 9:23pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 9:23pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 9:23pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:23pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 9:23pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:23pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 4:23pm ET |
| Benched | TE | Mason Taylor NYJ | Owner | Wed Nov 26 4:23pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 4:23pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Wed Nov 26 4:23pm ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 12:15am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 12:15am ET |
| Benched | TE | Noah Fant CIN | Owner | Wed Nov 26 2:01pm ET |
| Started | TE | David Njoku CLE | Owner | Wed Nov 26 2:01pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 8:38pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 8:38pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 10:01am ET |
| Benched | RB | Tahj Brooks CIN | Owner | Thu Nov 27 10:01am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 10:01am ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 10:01am ET |
| Started | RB | Samaje Perine CIN | Owner | Thu Nov 27 10:01am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 10:01am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Thu Nov 27 11:02am ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 11:02am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:31pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 1:31pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 1:31pm ET |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 1:31pm ET |