

| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 9:30am ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:30am ET |
| Benched | RB | Kyren Williams LAR | Owner | Sat Nov 29 3:06pm ET |
| Started | WR | Chris Olave NO | Owner | Sat Nov 29 3:06pm ET |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 25 4:33pm ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Nov 25 4:33pm ET |
| Benched | RB | Kyren Williams LAR | Owner | Tue Nov 25 8:09am ET |
| Benched | D/ST | Seattle Seahawks SEA | Owner | Tue Nov 25 8:09am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:09am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 8:09am ET |
| Benched | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:25pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:25pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 11:48am ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 11:05pm ET |
| Started | QB | Jordan Love GB | Owner | Wed Nov 26 11:05pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 10:59pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 10:59pm ET |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 11:01am ET |
| Started | WR | John Metchie III NYJ | Owner | Sun Nov 30 11:01am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Sun Nov 30 11:01am ET |
| Benched | QB | Cam Ward TEN | Owner | Wed Nov 26 7:28pm ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 7:28pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 7:28pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 7:28pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 7:28pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 7:28pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 3:22pm ET |
| Benched | K | Matt Gay SF | Owner | Wed Nov 26 3:22pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 3:22pm ET |
| Started | K | Chase McLaughlin TB | Owner | Wed Nov 26 3:22pm ET |
| Started | WR | Josh Downs IND | Owner | Thu Nov 27 8:34am ET |
| Benched | RB | Devin Neal NO | Owner | Tue Nov 25 3:10pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 25 3:10pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Tue Nov 25 3:10pm ET |
| Started | RB | Tony Pollard TEN | Owner | Tue Nov 25 3:10pm ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 25 2:49pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 2:49pm ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Cleveland Browns CLE | Owner | Sat Nov 29 10:20pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sat Nov 29 10:20pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 11:21pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 11:21pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 11:20pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 25 11:20pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 5:23pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 5:23pm ET |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 25 7:08pm ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 7:08pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 7:08pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:08pm ET |