

| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 8:45am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Wed Nov 26 8:45am CT |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 8:45am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:45am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 9:53am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:53am CT |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 1:00pm CT |
| Started | WR | Cooper Kupp SEA | Owner | Fri Nov 28 1:00pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 6:46am CT |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 6:46am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 7:06am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 7:06am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:06am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 7:06am CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Thu Nov 27 9:02am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 9:02am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 4:07pm CT |
| Benched | K | Michael Badgley IND | Owner | Wed Nov 26 4:07pm CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 4:07pm CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 4:07pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 26 10:03am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 10:03am CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:12pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 5:12pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 10:26am CT |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 10:26am CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 6:00pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 6:00pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 1:48pm CT |
| Started | RB | Woody Marks HOU | Owner | Tue Nov 25 1:48pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 3:31pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 3:31pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 3:30pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Wed Nov 26 3:30pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 3:30pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 3:30pm CT |
| Benched | RB | Tank Bigsby PHI | Owner | Thu Nov 27 11:28am CT |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 11:28am CT |
| Benched | QB | Jordan Love GB | Owner | Thu Nov 27 11:28am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 11:28am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 11:26am CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:26am CT |
| Started | RB | Dylan Sampson CLE | Owner | Thu Nov 27 11:26am CT |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 11:26am CT |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 9:38am CT |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 9:38am CT |