

| Started | QB | Baker Mayfield TB | Owner | Fri Nov 28 8:21pm CT |
| Benched | QB | Tua Tagovailoa MIA | Owner | Fri Nov 28 8:21pm CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:29pm CT |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 3:29pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 4:03pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:03pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 4:03pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 4:03pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 4:03pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 4:03pm CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 4:03pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 4:03pm CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 11:36am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 11:36am CT |
| Benched | RB | Blake Corum LAR | Owner | Tue Nov 25 1:26pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:26pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 1:26pm CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 1:26pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 25 1:26pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 1:26pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 1:26pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:26pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 2:35pm CT |
| Started | WR | Chimere Dike TEN | Owner | Fri Nov 28 2:35pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 25 4:10pm CT |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 25 4:10pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 4:09pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 4:09pm CT |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 4:09pm CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 4:09pm CT |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 25 8:07am CT |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 8:07am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:07am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:07am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 7:04am CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 7:04am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 6:19am CT |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 25 6:19am CT |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 6:19am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 6:19am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:19am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:19am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 4:00pm CT |
| Benched | RB | Travis Etienne JAX | Owner | Tue Nov 25 3:57pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 3:57pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:57pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 3:48pm CT |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 3:48pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 1:56pm CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 1:56pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 1:56pm CT |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 25 1:56pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 8:11am CT |
| Benched | TE | Theo Johnson NYG | Owner | Sat Nov 29 8:11am CT |
| Started | TE | Theo Johnson NYG | Owner | Thu Nov 27 7:37pm CT |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 7:37pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 7:55pm CT |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 7:55pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 11:56am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 11:56am CT |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 7:23pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 7:23pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:01am CT |
| Benched | RB | Brian Robinson Jr. SF | Owner | Tue Nov 25 11:01am CT |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 25 9:51am CT |
| Benched | WR | Devaughn Vele NO | Owner | Tue Nov 25 9:51am CT |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 9:51am CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 9:51am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 6:15am CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 6:15am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:15am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:15am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Fri Nov 28 12:04am CT |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 12:04am CT |
| Benched | QB | Caleb Williams CHI | Owner | Fri Nov 28 12:03am CT |
| Started | QB | Jacoby Brissett ARI | Owner | Fri Nov 28 12:03am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Nov 27 7:30am CT |
| Started | QB | Caleb Williams CHI | Owner | Thu Nov 27 7:30am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:10am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 7:10am CT |