

| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 8:48am ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 8:48am ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 8:48am ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 8:48am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 8:48am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:48am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 9:33am ET |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 9:33am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 9:33am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 9:33am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 9:33am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:33am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 7:44am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Fri Nov 28 7:44am ET |
| Started | RB | Zonovan Knight ARI | Owner | Wed Nov 26 8:29am ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 8:29am ET |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 25 8:31am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 8:31am ET |
| Started | WR | Mack Hollins NE | Owner | Tue Nov 25 8:29am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 8:29am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:28am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 8:28am ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 8:28am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:28am ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 8:28am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 8:28am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 8:26am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 12:43pm ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Wed Nov 26 12:43pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 12:43pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 12:43pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 10:57pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 10:57pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:58am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:58am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:58am ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:58am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 12:44pm ET |
| Started | RB | Tony Pollard TEN | Owner | Thu Nov 27 12:44pm ET |
| Benched | QB | Mason Rudolph PIT | Owner | Thu Nov 27 1:48am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 1:48am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 1:48am ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 27 1:48am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 12:29pm ET |
| Started | WR | Malik Washington MIA | Owner | Thu Nov 27 12:29pm ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 3:40pm ET |
| Started | WR | John Metchie III NYJ | Owner | Wed Nov 26 3:40pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 3:39pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 3:39pm ET |
| Benched | QB | Tyler Shough NO | Owner | Wed Nov 26 11:56pm ET |
| Benched | RB | Brashard Smith KC | Owner | Wed Nov 26 11:56pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 11:56pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 11:56pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 11:56pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 26 11:56pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 11:56pm ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 11:56pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 10:50am ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Thu Nov 27 10:50am ET |
| Started | WR | Chimere Dike TEN | Owner | Sat Nov 29 1:28pm ET |
| Benched | TE | Tyler Warren IND | Owner | Sat Nov 29 1:28pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:56am ET |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 9:56am ET |
| Started | WR | Courtland Sutton DEN | Owner | Sat Nov 29 9:32am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:32am ET |
| Benched | RB | Aaron Jones MIN | Owner | Sat Nov 29 9:05am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 9:05am ET |
| Started | TE | Tyler Warren IND | Owner | Sat Nov 29 8:58am ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 8:58am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Sat Nov 29 8:58am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Sat Nov 29 8:58am ET |
| Started | WR | D.J. Moore CHI | Owner | Fri Nov 28 11:34am ET |
| Benched | TE | Tyler Warren IND | Owner | Fri Nov 28 11:34am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 8:19am ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 8:19am ET |
| Started | WR | D.J. Moore CHI | Owner | Thu Nov 27 8:18am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Thu Nov 27 8:18am ET |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 2:55pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 26 2:55pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 25 9:20pm ET |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 25 9:20pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:56am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 11:56am ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:23am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:23am ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 8:23am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 8:23am ET |