

| Benched | WR | Troy Franklin DEN | Owner | Tue Dec 9 9:00pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Dec 9 9:00pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Dec 9 9:00pm ET |
| Started | TE | Dalton Schultz HOU | Owner | Tue Dec 9 9:00pm ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Sun Dec 14 10:47am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Sun Dec 14 10:47am ET |
| Benched | WR | Romeo Doubs GB | Owner | Thu Dec 11 6:23am ET |
| Started | WR | Jauan Jennings SF | Owner | Thu Dec 11 6:23am ET |
| Benched | TE | Colby Parkinson LAR | Owner | Tue Dec 9 10:39am ET |
| Started | TE | George Kittle SF | Owner | Tue Dec 9 10:39am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Fri Dec 12 8:46pm ET |
| Started | WR | D.K. Metcalf PIT | Owner | Fri Dec 12 8:46pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Thu Dec 11 5:01pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Dec 11 5:01pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Thu Dec 11 5:01pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Dec 11 5:01pm ET |
| Benched | RB | Samaje Perine CIN | Owner | Sun Dec 14 12:50pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Sun Dec 14 12:50pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Sun Dec 14 12:50pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Sun Dec 14 12:50pm ET |
| Started | D/ST | Chicago Bears CHI | Owner | Sun Dec 14 10:41am ET |
| Benched | QB | Jared Goff DET | Owner | Tue Dec 9 9:04am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Dec 9 9:04am ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Dec 9 9:04am ET |
| Started | QB | Brock Purdy SF | Owner | Tue Dec 9 9:04am ET |
| Started | RB | Kyren Williams LAR | Owner | Tue Dec 9 9:04am ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Dec 9 9:04am ET |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Sat Dec 13 3:41pm ET |
| Started | TE | Isaiah Likely BAL | Owner | Sat Dec 13 3:41pm ET |
| Benched | RB | David Montgomery DET | Owner | Thu Dec 11 11:22pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Thu Dec 11 11:22pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Dec 9 8:46am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Dec 9 8:46am ET |
| Benched | RB | Jordan Mason MIN | Owner | Thu Dec 11 7:28pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Dec 11 7:28pm ET |
| Started | RB | Rico Dowdle CAR | Owner | Thu Dec 11 7:28pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Thu Dec 11 7:28pm ET |
| Benched | WR | Jameson Williams DET | Owner | Sun Dec 14 8:35am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Sun Dec 14 8:35am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Thu Dec 11 5:49pm ET |
| Started | WR | Jameson Williams DET | Owner | Thu Dec 11 5:49pm ET |
| Benched | WR | Jameson Williams DET | Owner | Thu Dec 11 12:15pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Dec 11 12:15pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Thu Dec 11 9:24am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Dec 11 9:24am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Tyrod Taylor NYJ | Owner | Thu Dec 11 10:09am ET |
| Started | QB | Marcus Mariota WAS | Owner | Thu Dec 11 10:09am ET |