

| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 25 9:45pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 9:45pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 9:45pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:45pm CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 9:32am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:32am CT |
| Benched | D/ST | Seattle Seahawks SEA | Owner | Tue Nov 25 9:32am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:32am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 9:32am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 9:32am CT |
| Benched | D/ST | Indianapolis Colts IND | Owner | Thu Nov 27 8:22am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 8:22am CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Wed Nov 26 7:38am CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 7:38am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 12:25pm CT |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 12:25pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 3:24pm CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 3:24pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 3:24pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 3:24pm CT |
| Benched | K | Chase McLaughlin TB | Owner | Thu Nov 27 1:06pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 1:06pm CT |
| Benched | RB | Isiah Pacheco KC | Owner | Thu Nov 27 8:53am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 8:53am CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 5:07pm CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 5:07pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 5:07pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Nov 26 5:07pm CT |
| Benched | K | Chris Boswell PIT | Owner | Wed Nov 26 3:31pm CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 3:31pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 7:08am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:08am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 8:09am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 8:09am CT |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 27 9:43am CT |
| Benched | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 9:43am CT |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 1:58pm CT |
| Benched | TE | Evan Engram DEN | Owner | Wed Nov 26 1:58pm CT |
| Started | TE | Evan Engram DEN | Owner | Wed Nov 26 1:57pm CT |
| Benched | TE | David Njoku CLE | Owner | Wed Nov 26 1:57pm CT |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 26 8:58am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 8:58am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:58am CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 8:58am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Geno Smith LV | Owner | Thu Nov 27 8:10am CT |
| Started | QB | Tyrod Taylor NYJ | Owner | Thu Nov 27 8:10am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 7:16pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 7:16pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 5:14pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 5:14pm CT |
| Started | QB | Geno Smith LV | Owner | Tue Nov 25 5:14pm CT |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 5:14pm CT |