

| Benched | QB | J.J. McCarthy MIN | Owner | Fri Nov 28 10:40pm CT |
| Started | QB | Brock Purdy SF | Owner | Fri Nov 28 10:40pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 4:11pm CT |
| Benched | TE | George Kittle SF | Owner | Tue Nov 25 4:11pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 4:11pm CT |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 25 4:11pm CT |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 5:19pm CT |
| Started | QB | Sam Darnold SEA | Owner | Thu Nov 27 5:19pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:39am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 8:39am CT |
| Benched | QB | Mason Rudolph PIT | Owner | Tue Nov 25 1:33pm CT |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 1:33pm CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 1:33pm CT |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Tue Nov 25 1:33pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 1:33pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:33pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:33pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:33pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Sat Nov 29 5:13pm CT |
| Started | QB | Max Brosmer MIN | Owner | Sat Nov 29 5:13pm CT |
| Benched | WR | Darius Slayton NYG | Owner | Wed Nov 26 3:26pm CT |
| Started | RB | Rachaad White TB | Owner | Wed Nov 26 3:26pm CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 3:25pm CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 3:25pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 9:47am CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 9:47am CT |
| Benched | QB | Justin Fields NYJ | Owner | Tue Nov 25 9:46am CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 9:46am CT |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 8:24am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 8:24am CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 9:12am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 9:12am CT |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 9:12am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:12am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:12am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:12am CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 10:49am CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:49am CT |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 10:46am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Thu Nov 27 10:46am CT |
| Benched | WR | Cedric Tillman CLE | Owner | Thu Nov 27 10:46am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 10:46am CT |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 10:46am CT |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 10:46am CT |