

| Benched | WR | Chris Olave NO | Owner | Sat Nov 29 7:43pm ET |
| Started | WR | D.K. Metcalf PIT | Owner | Sat Nov 29 7:43pm ET |
| Benched | TE | Tyler Warren IND | Owner | Sat Nov 29 7:43pm ET |
| Started | TE | Brenton Strange JAX | Owner | Sat Nov 29 7:43pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 8:08am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:08am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 7:38pm ET |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 7:38pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:25am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 7:25am ET |
| Started | RB | Jordan Mason MIN | Owner | Tue Nov 25 7:25am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 7:25am ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 25 9:56am ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 9:56am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 9:56am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:56am ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 9:54am ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 9:54am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 25 9:52am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 9:52am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 9:52am ET |
| Benched | K | Chad Ryland ARI | Owner | Tue Nov 25 9:52am ET |
| Started | K | Cam Little JAX | Owner | Sun Nov 30 5:58am ET |
| Benched | K | Cairo Santos CHI | Owner | Thu Nov 27 8:11pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Thu Nov 27 7:40am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 7:40am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 4:23pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 4:23pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 11:02pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 11:02pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 6:59pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 6:59pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 2:47pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 2:47pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 11:25am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 11:25am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 9:14am ET |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 9:14am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 12:10pm ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 12:10pm ET |
| Benched | K | Chris Boswell PIT | Owner | Thu Nov 27 12:10pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Thu Nov 27 12:10pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 12:10pm ET |
| Started | TE | Chigoziem Okonkwo TEN | Owner | Thu Nov 27 12:10pm ET |
| Started | K | Jason Myers SEA | Owner | Thu Nov 27 12:10pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 12:10pm ET |
| Benched | QB | Jalen Hurts PHI | Owner | Thu Nov 27 10:33pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Thu Nov 27 10:33pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 10:33pm ET |
| Started | TE | Gunnar Helm TEN | Owner | Thu Nov 27 10:33pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 9:04am ET |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 9:22am ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 9:22am ET |
| Started | WR | Jordan Addison MIN | Owner | Wed Nov 26 9:22am ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 9:22am ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 9:22am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 9:22am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Sun Nov 30 4:05am ET |
| Started | WR | Greg Dortch ARI | Owner | Sun Nov 30 4:05am ET |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 2:31am ET |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 26 2:31am ET |