

| Benched | WR | Jakobi Meyers JAX | Owner | Sat Nov 29 10:42pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 10:42pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Thu Nov 27 4:58pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 25 5:18pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 5:18pm ET |
| Benched | K | Jake Bates DET | Owner | Tue Nov 25 5:18pm ET |
| Started | RB | Isiah Pacheco KC | Owner | Tue Nov 25 5:18pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 5:18pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 10:25am ET |
| Started | WR | Drake London ATL | Owner | Thu Nov 27 10:25am ET |
| Benched | QB | Bo Nix DEN | Owner | Thu Nov 27 7:39am ET |
| Started | QB | Dak Prescott DAL | Owner | Thu Nov 27 7:39am ET |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 26 4:23pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:23pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 4:23pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 4:23pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 10:29am ET |
| Benched | WR | Xavier Worthy KC | Owner | Thu Nov 27 10:29am ET |
| Benched | TE | Evan Engram DEN | Owner | Thu Nov 27 10:29am ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 10:29am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 10:29am ET |
| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 10:29am ET |
| Benched | WR | Stefon Diggs NE | Owner | Sun Nov 30 12:23am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Sun Nov 30 12:23am ET |
| Benched | RB | Travis Etienne JAX | Owner | Thu Nov 27 10:22am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 10:22am ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 8:31pm ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 8:31pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:30pm ET |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 25 8:30pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Nov 25 8:30pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 25 8:30pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 5:18pm ET |
| Benched | D/ST | New Orleans Saints NO | Owner | Thu Nov 27 5:18pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Thu Nov 27 5:18pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 5:18pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 3:34pm ET |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 3:34pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 26 6:01pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 6:01pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 5:58pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 5:58pm ET |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 2:36am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 2:36am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 5:25pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 5:25pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 5:25pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 5:25pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 2:40am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 2:40am ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 2:40am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 2:40am ET |