

| Benched | WR | Rome Odunze CHI | Owner | Thu Nov 27 2:21pm CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 2:21pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 6:58pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:58pm CT |
| Started | QB | Baker Mayfield TB | Owner | Fri Nov 28 7:37pm CT |
| Benched | QB | Tyrod Taylor NYJ | Owner | Fri Nov 28 7:37pm CT |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:24pm CT |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 3:24pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 3:16pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:16pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 3:16pm CT |
| Benched | TE | Brock Wright DET | Owner | Tue Nov 25 3:16pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 3:16pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 3:16pm CT |
| Benched | WR | Drake London ATL | Owner | Fri Nov 28 1:00pm CT |
| Started | WR | Keon Coleman BUF | Owner | Fri Nov 28 1:00pm CT |
| Benched | QB | Cam Ward TEN | Owner | Wed Nov 26 6:36am CT |
| Benched | WR | Kendrick Bourne SF | Owner | Wed Nov 26 6:36am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 6:36am CT |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 6:36am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 4:19pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 4:19pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:19pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 4:19pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 9:51am CT |
| Started | RB | Tony Pollard TEN | Owner | Thu Nov 27 9:51am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Trey Benson ARI | Owner | Thu Nov 27 4:35pm CT |
| Started | RB | Tank Bigsby PHI | Owner | Thu Nov 27 4:35pm CT |
| Benched | RB | Blake Corum LAR | Owner | Thu Nov 27 12:09am CT |
| Benched | WR | Tez Johnson TB | Owner | Thu Nov 27 12:09am CT |
| Benched | WR | Adonai Mitchell NYJ | Owner | Thu Nov 27 12:09am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:09am CT |
| Started | RB | Trey Benson ARI | Owner | Thu Nov 27 12:09am CT |
| Started | WR | Quentin Johnston LAC | Owner | Thu Nov 27 12:09am CT |
| Benched | QB | Davis Mills HOU | Owner | Tue Nov 25 9:46pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 9:46pm CT |
| Benched | WR | Sterling Shepard TB | Owner | Tue Nov 25 8:24pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:24pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 8:24pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 8:24pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 10:27am CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 10:27am CT |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 10:27am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 10:27am CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 10:27am CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 10:27am CT |
| Benched | WR | Josh Downs IND | Owner | Fri Nov 28 8:12am CT |
| Started | WR | Greg Dortch ARI | Owner | Fri Nov 28 8:12am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 1:11am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 1:11am CT |